immunologic prevention of iddm by oral administration of glutamic acid decarboxylase
نویسندگان
چکیده
we have investigated the preventive effects of oral administration of isolated e.coli ghttam'tc acid decarboxylase (gad) in animal models. based on our results, the blood glucose levels were reduced by oral administration of gad to rats 14 days before intraperitoneal injections of streptozocin (40 mg/kg on five consecutive days). on the other hand, oral administration of gad to rats before streptozocin treatment significantly (p
منابع مشابه
Two distinct glutamic acid decarboxylase auto-antibody specificities in IDDM target different epitopes.
Although most individuals with insulin-dependent diabetes mellitus (IDDM) have autoantibodies to glutamic acid decarboxylase (GAD), antibodies to GAD are also present in some individuals with a low risk of developing diabetes. The GAD autoantibodies of IDDM are specific for the GAD65 isoform, do not bind denatured GAD protein, and target epitope(s) dependent on conformation of the protein. Howe...
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IMPORTANCE Current clinical and immunologic knowledge on cerebellar ataxia (CA) with glutamic acid decarboxylase 65 antibodies (GAD65-Abs) is based on case reports and small series with short-term follow-up data. OBJECTIVE To report the symptoms, additional antibodies, prognostic factors, and long-term outcomes in a cohort of patients with CA and GAD65-Abs. DESIGN, SETTING, AND PARTICIPANTS...
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متن کاملDetermination of Glycyrrhetic Acid in Rat Plasma by HPLC After Oral Administration of Licorice Aqueous Extract
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عنوان ژورنال:
acta medica iranicaجلد ۳۷، شماره ۴، صفحات ۱۹۹-۲۰۳
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